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Although we're hearing about vaccines a lot in the news recently, vaccines have been with us for hundreds of years.
The story of vaccines and immunizations begins in 1796 when Dr. Edward Jenner, whose work is the bedrock of modern immunology, performed the first immunization in England. He inoculated a young boy with cowpox, which is similar to smallpox but has much milder effects. Six weeks later, Jenner exposed the boy to smallpox. The boy did not develop the deadly disease.
Since then, vaccines have become a powerful tool to prevent us from getting many contagious diseases, such as measles, hepatitis and the seasonal flu.
Vaccines work by triggering your immune system army -- without making you sick -- and they give your body a competitive edge against fighting illness.
The immune system is divided into two battalions. Your body's first team of immune system army troops is rapidly called to action without even knowing exactly who the enemy is. These cells attack invaders by doing everything from causing a fever that can make an infectious invader uncomfortably hot inside of your body to triggering other immune cells to release chemical destroyer signals that are directly toxic to the enemy pathogen.
If the infectious invader breaches that first line of defense, the second battalion, called the adaptive immune response, is called into action. This is the line of defense that vaccines trigger and train to learn exactly what an infectious enemy like COVID-19 looks like. In this battalion, the soldiers are called B-cells and T-cells.
One type of T-cells, called helper T-cells, coordinates the adaptive immune troops. When helper T-cells find traces of an infectious invader in your body, they coordinate an adaptive immune response by recruiting B-cells and another type of T-cell called a killer T-cell. When B-cells confront an enemy virus, they begin a process of producing just the right configuration of antibodies that will attack, neutralize or help make it easier for the virus to be destroyed by the first immune system battalion.
Meanwhile, killer T-cells focus on destroying cells that have already been infected by the virus. Because sick cells present bits of an enemy virus on their surface, killer T-cells are trained to target and destroy these specific cells without harming other healthy cells.
Once your immune system army successfully defeats an infectious invader, your body stores this knowledge in troops called memory cells, which can be called on in the future if your body encounters the enemy again.
This is how vaccinations work. They provide a safe and effective way for your body to practice how to fight specific invaders, like the coronavirus, and they prepare your immune system army to be called to action when needed.
abc news
As the French President Emmanuel Macron faces accusations that he is moving to curtail the civic rights in his country and reduce transparency, the recent state visit of Egyptian President Abdel Fattah al-Sisi underscored France’s longstanding willingness to turn a blind eye to systemic oppression in the countries it sells weapons to.
When Sisi came to France for a state visit this week, less than a month after prominent human rights workers in Egypt were arrested and slapped with terrorism-related charges following a meeting with French and other European diplomats, Human Rights Watch called for arms sales to Egypt to stop and activists were looking to French President Emmanuel Macron to make a strong statement.
They had, perhaps, reason to be hopeful. After the November arrests, the French Foreign Ministry issued a statement expressing its “deep concern” about developments in the Arab nation. “France maintains a frank, exacting dialogue with Egypt on human rights issues, including individual cases,” the statement said.
In the end, not only were activists disappointed by Macron’s reception of Sisi, they were outraged by it. Far from taking a firm line on abuses and demanding that Egypt do better if it hoped to continue receiving military aid, Macron went out of his way to disassociate the purchase of arms with the respect of human rights.
“I will not condition matters of defence and economic cooperation on these disagreements [over human rights],” Macron said in a press conference. "It is more effective to have a policy of demanding dialogue than a boycott that would only reduce the effectiveness of one of our partners in the fight against terrorism."
“The whole way he framed the human rights debate in the press conference was horrific,” said Timothy Kaldas, Nonresident fellow at the Tahrir Institute for Middle East Policy. “Arresting human rights workers and oppressing Egyptians is not fighting terrorism. Quite the contrary.”
A double standard
Macron’s stance was particularly salient given that his own government has been under fire over a proposed security law that critics charge would limit civic liberties in France. At the same time that he has defended France’s commitment to freedom of speech in the wake of the killing of a teacher who showed his class caricatures of the prophet Mohammed. Macron called the teacher, Samuel Paty, a “quiet hero” dedicated to preserving French values.
Macron’s position with Sisi this week was notably softer than the one he took in January 2019, when he told his Egyptian counterpart that security could not be considered separately from human rights, noting that oppression jeopardises stability rather than enhance it.
“It’s a double standard,” said Rim-Sarah Alouane, a Researcher in Public Law, University Toulouse Capitole. “We are in the middle of this hypocrisy about how we are supposed to be the country of the enlightenment, of human rights – we are supposed to have basically created human rights – and yet we have no problem making deals with the devil and closing our eyes to what should be the most important thing: the protection of the human.”
Kaldas agreed: “[Macron] will be adamant about how much France cherishes its values in one context and then be completely unwilling to prioritise those values in his relations with authoritarians.”
Marcon has shown himself similarly willing to ignore abuses in other parts of the region as well. When several European countries, including Germany, called for the suspension of arms sales to Saudi Arabia after the murder of journalist Jamal Khashoggi, Macron dismissed those concerns as “demagoguery”, saying the weapons had nothing to do with the murder. “I understand the connection with what’s happening in Yemen, but there is no link with Mister Khashoggi,” he said.
Saudi Arabia leads a coalition that has been engaged in a war in Yemen that has had devastating effects on the humanitarian situation there. “The only reason [Macron] cites Yemen is to dismiss the other argument, but then he continues to provide the arms that fuel the war in Yemen,” Kaldas said.
Key to sovereignty
France has a vested interest in batting away the issue of rights abuses. Arms sales are big business for the country, which is third in global military exports, coming behind the United States and Russia. The defence sector in France employs 200,000 people, roughly 13 percent of the total industrial workforce, according to a report by the country's parliament.
France is one of the few countries in the world capable of independently producing advanced military systems, and arms sales are key to the survival of the defence sector.
“It’s important for France to maintain its own arms industry,” both to be a significant player on the world stage and to be self-sufficient, said Pieter D. Wezeman, Senior Researcher in the Arms and Military Expenditure Programme at the Stockholm International Peace Research Institute. “To be able to do that, you need to have export clients, because otherwise you won’t be able to afford it.”
As Minister of the Armed Forces Florence Parly put it in 2018: “Arms exports are the business model of our sovereignty.”
And the industry is growing. Arms sales can vary widely from year to year, so researchers look at extended periods of time. Comparing the years 2015-2019 with 2010-2014, French arms exports grew 72 percent, representing 7.9 percent of the global arms market. Over the past decade, the Middle East has accounted for roughly 48 percent of French exports, said Guy Anderson, Associate Director of the Industry and Markets division at Jane's, publisher of Jane's Defence Weekly.
“France has been very prolific in providing weapons to a wide range of people,” Wezeman said.
France has been known to ignore arms embargos as well. In his autobiography “No Room for Small Dreams,” the late Israeli politician Shimon Perez said that France secretly sold weapons to Israel back in the 1950s, when few nations would. And it was the French who gave Israel its nuclear capacities, Perez wrote.
The illicit arms sales have continued. The French found ways to supply weapons to the apartheid regime in South Africa despite restrictions on such exports and press reports said that military material found in Libya in 2019 indicated that France had violated the arms embargo there.
“France is one of the least scrupulous arms sellers on earth,” said Kaldas. “Even the US is a little more restrictive about their arms sales.”
The delegation represented by head of Ansaldo Energia Marino Giuseppe has met with the head of Azerenergy OJSC Baba Rzayev, Azerenergy told APA-Economics.
Touching upon friendship and cooperation issues between Italy-Azerbaijan B. Rzayev highly appreciated Italy’s position in the settlement of the Nagorno-Karabakh conflict, which is the righteous work of Azerbaijan.
He recalled that a delegation of the Ministry of Foreign Affairs and International Cooperation of the Italian Republic visited Ganja and the liberated city of Aghdam on September 9 and shared their impressions of seeing the destruction here.
Noting that Azerenergy cooperates with a number of international giants, Rzayev said the main purpose of the meeting was to create a new, modern type of electricity infrastructure in the liberated territories of Azerbaijan. "For 30 years, the Armenian occupiers have caused serious damage to all infrastructure, including power plants, in these areas, which are the ancient historical lands of Azerbaijan. Now there is almost no energy infrastructure in these areas."
Rzayev informed the guests about the opportunities for cooperation on a number of projects, including the establishment of a working group between the companies and the office of Ansaldo Energia in Baku.
The meeting focused on the joint implementation of new small hydropower projects in Kalbajar and Lachin regions, the participation of Ansaldo Energia in the construction and supply of high-voltage substations in the liberated areas, frequency regulation (Baku). Cooperation with Ansaldo Energia in the project of a new 390 MW power plant planned to be built in BOT format, application of software and new technology to improve the management of the transmission system operator of Azerenergy OJSC, general management of Azerenergy OJSC. The sides exchanged views on the establishment of a training center in the scientific-educational and laboratory complex, consisting of equipment manufactured by Ansaldo Energia.
The head of Ansaldo Energia, Marino Guiseppe, praised Ansaldo Energia's proposal to establish an office in Baku, saying that his country was at the forefront of producing high-tech equipment to supply power plants to be reconstructed on the orders of Azerenergy.
The issue of governance and political authority in the Muslim world will be up for discussion at an international virtual conference set to begin Saturday afternoon.
“The discussion will require going back to fundamental questions around leadership without authoritarianism and despotism,” said a statement by the Center for Islam and Global Affairs (CIGA), the host think-tank based in Istanbul, Turkey.
At the conference, running online through next week, over 60 speakers from 20 countries will “explore new models of sovereignty which balance modern ideas of citizenship, the rule of law, and democracy with traditional values.”
Among slated speakers are former Malaysian Deputy Prime Minister Anwar Ibrahim and Gulnur Aybet, a senior advisor to Turkish President Recep Tayyip Erdogan.
Sami A. Al-Arian, the center’s director, told Anadolu Agency: “The conference panels will not only analyze issues of governance and political authority in the Muslim world but will also attempt to present practical responses to difficult challenges.”
This will be the fourth, but first virtual, “Muslim Ummah” conference hosted by the center, affiliated to Istanbul Sabahattin Zaim University since the think tank was launched in 2017.
“This event is in the CIGA tradition of organizing one conference every year discussing in an academic forum the affairs of the Muslim world both at the intellectual and political levels,” said Al-Arian, adding that the think tank has held over 50 webinars since the pandemic hit the world.
“Since there are different time zones of presenters [speakers] from around the world, there will be only two sessions per day, which would extend the conference to seven days,” the center said./aa
Turkey's benchmark stock index hit an all-time high at Friday's close, reaching 1,370.70 points, up 1.28%.
After starting the day at 1,350.31 points, Borsa Istanbul's BIST 100 index earned 17.34 points over Thursday's close of 1,353.36 points.
During the day, the index hovered between 1,342.58 and 1,371.00 points.
The total market value of the BIST 100 was around one trillion Turkish liras ($129 billion) by market close, with a daily trading volume of 30.6 billion Turkish liras ($3.91 billion).
On the last transaction day of the week, 34 stocks on the index rose, 62 fell and four were flat compared to Thursday.
The highest trading volumes were posted by glass manufacturer Sisecam, private lender Garanti BBVA, and petrochemical company Petkim.
Tractor producer Tumosan was the best performer, with its shares up 10.0%, while stocks of Selcuk Ecza Deposu, a pharmaceutical supplier, dropped the most, losing 6.52%.
The price of one ounce of gold was $1,834.50 by market close, up from $1,819.00 at the previous close, according to data from Borsa Istanbul's Precious Metals and Diamond Markets.
The price of Brent crude oil was around $50.2 per barrel as of 6.10 p.m. local time (1810GMT) on Friday./aa
Matt Richtel
Alice McGraw, 2 years old, was walking with her parents in Lake Tahoe this summer when another family appeared, heading in their direction. The little girl stopped.
“Uh-oh,” she said and pointed: “People.”
She has learned, her mother said, to keep the proper social distance to avoid risk of infection from the coronavirus. In this and other ways, she’s part of a generation living in a particular new type of bubble — one without other children. They are the toddlers of COVID-19.
Gone for her and many peers are the play dates, music classes, birthday parties, the serendipity of the sandbox or the side-by-side flyby on adjacent swingsets. Many families skipped day care enrollment in the fall, and others have withdrawn amid the new surge in coronavirus cases.
With months of winter isolation looming, parents are growing increasingly worried about the developmental effects of the ongoing social deprivation on their very young children.
“People are trying to weight pros and cons of what’s worse: putting your child at risk for COVID or at risk for severe social hindrance,” said Suzanne Gendelman, whose daughter, Mila, 14 months old, regularly spent rug time with Alice McGraw before the pandemic.
“My daughter has seen more giraffes at the zoo more than she’s seen other kids,” Gendelman said.
It is too early for published research about the effects of the pandemic lockdowns on very young children, but childhood development specialists say that most children will likely be OK because their most important relationships at this age are with parents.
Still, a growing number of studies highlight the value of social interaction to brain development. Research shows that neural networks influencing language development and broader cognitive ability get built through verbal and physical give-and-take — from the sharing of a ball to exchanges of sounds and simple phrases.
These interactions build “structure and connectivity in the brain,” said Kathryn Hirsh-Pasek, director of the Infant Language Laboratory at Temple University and a senior fellow at the Brookings Institution. “They seem to be brain feed.”
In infants and toddlers, these essential interactions are known as “serve-and-return,” and rely on seamless exchanges of guttural sounds or simple words.
Hirsh-Pasek and others say that technology presents both opportunity and risk during the pandemic. On one hand, it allows children to engage in virtual play by Zoom or FaceTime with grandparents, family friends or other children. But it can also distract parents who are constantly checking their phones to the point that the device interrupts the immediacy and effectiveness of conversational duet — a concept known as “technoference.”
John Hagen, professor emeritus of psychology at the University of Michigan, said he would be more concerned about the effect of lockdowns on young children, “if this were to go on years and not months.”
“I just think we’re not dealing with any kinds of things causing permanent or long-term difficulties,” he said.
Hirsh-Pasek characterized the current environment as a kind of “social hurricane” with two major risks: Infants and toddlers don’t get to interact with one another and, at the same time, they pick up signals from their parents that other people might be a danger.
“We’re not meant to be stopped from seeing the other kids who are walking down the street,” she said.
Just that kind of thing happened to Casher O’Connor, 14 months, whose family recently moved to Portland, Oregon, from San Francisco. Several months before the move, the toddler was on a walk with his mother when he saw a little boy nearby.
“Casher walked up to the 2-year-old, and the mom stiff-armed Cash not to get any closer,” said Elliott O’Connor, Casher’s mother.
“I understand,” she added, “but it was still heartbreaking.”
Portland has proved a little less prohibitive place for childhood interaction in part because there is more space than in the dense neighborhoods of San Francisco, and so children can be in the same vicinity without the parents feeling they are at risk of infecting one another.
“It’s amazing to have him stare at another kid,” O’Connor said.
“Seeing your kid playing on a playground with themselves is just sad,” she added. “What is this going to be doing to our kids?”
The rise of small neighborhood pods or of two or three families joining together in shared bubbles has helped to offset some parents’ worries. But new tough rules in some states, like California, have disrupted those efforts because playgrounds have been closed in the latest COVID-19 surge and households have been warned against socializing outside their own families.
Plus, the pods only worked when everyone agreed to obey the same rules, and so some families simply chose to go it alone.
That’s the case of Erinn and Craig Sheppard, parents of a 15-month-old, Rhys, who live in Santa Monica, California. They are particularly careful because they live near the little boy’s grandmother, who is in her 80s. Sheppard said Rhys has played with “zero” children since the pandemic started.
“We get to the park, we Clorox the swing and he gets in and he has a great time and loves being outside and he points at other kids and other parents like a toddler would,” she said. But they don’t engage.
One night, Rhys was being carried to bed when he started waving. Sheppard realized that he was looking at the wall calendar, which has babies on it. It happens regularly now. “He waves to the babies on the wall calendar,” Sheppard said.
Experts in child development said it would be useful to start researching this generation of children to learn more about the effects of relative isolation. There is a distant precedent: Research was published in 1974 that tracked children who lived through a different world-shaking moment, the Great Depression. The study offers reason for hope.
“To an unexpected degree, the study of the children of the Great Depression followed a trajectory of resilience into the middle years of life,” wrote Glen Elder, author of that research.
Brenda Volling, a psychology professor at the University of Michigan and an expert in social and emotional development, said one takeaway is that Depression-era children who fared best came from families who overcame the economic fallout more readily and who, as a result, were less hostile, angry and depressed.
To that end, what infants, toddlers and other children growing up in the COVID era need most now is stable, nurturing and loving interaction with their parents, Volling said.
“These children are not lacking in social interaction,” she said, noting that they are getting “the most important” interaction from their parents.
A complication may involve how the isolation felt by parents causes them to be less connected to their children.
“They are trying to manage work and family in the same environment,” Volling said. The problems cascade, she added, when parents grow “hostile or depressed and can’t respond to their kids, and get irritable and snap.”
“That’s always worse than missing a play date.”
The New York Times.
An update to the International Union for Conservation of Nature's Red List of Threatened Species has declared 31 animal and plant species extinct.
That total includes the lost shark, listed as critically endangered or possibly extinct, as it was last recorded in 1934, the ICUN announced on Thursday. The lost shark's habitat in the South China Sea, one of the world's most exploited marine regions, has been extensively fished for more than a century.
It's unlikely the lost shark's population could have persisted under current conditions, so it's probably already extinct, according to the ICUN.
Out of 17 freshwater fish species in Lake Lanao and its outlet in the Philippines, 15 are now extinct and two are critically endangered or possibly extinct, the ICUN announced. The extinctions were caused by predatory introduced species as well as overharvesting and destructive fishing methods.
In Central America, three frog species have now been declared extinct. Another 22 frog species across Central and South America are listed as critically endangered or possibly extinct -- with the driver of the declines identified as chytridiomycosis disease, an infectious disease caused by a fungus that affects amphibians worldwide.
In addition, all of the species of freshwater dolphin in the world are now threatened with extinction, with the addition of the tucuxi, a freshwater dolphin species found in the Amazon river system, to the list, according to the ICUN. The tucuxi population has been "severely depleted" by deaths linked to fishing gear, damming rivers and pollution. The priority actions to recover the species include eliminating the use of gillnets -- curtains of fishing net that hang in the water, reducing the number of dams in its habitat and enforcing the ban on deliberately killing them.
In the plant world, the ICUN has found that nearly a third of oak trees around the world are threatened with extinction, with the highest numbers in China and Mexico, followed by Vietnam, the U.S. and Malaysia. Land clearance for logging and agriculture are the most common threats, as well as invasive alien species and diseases, and climate change.
Species that have recovered include the European bison, the largest land mammal in Europe, which has progressed from vulnerable to near-threatened. The population has grown from about 1,800 in 2003 to more than 6,200 in 2019 after surviving only in captivity in the early 20th century. It was reintroduced to the wild in the 1950s, and the largest subpopulations are found in Poland, Belarus and Russia.
Currently, there are 47 free-ranging European bison herds, but they're largely isolated from one another and confined to suboptimal forest habitats, according to the ICUN. Only eight of the herds are large enough to be genetically viable in the long term, so the species will remain dependent on conservation efforts, such as moving them to more optimal, open habitats, and reducing conflicts with humans.
The outlook for 25 other species has also improved, which demonstrates "the power of conservation," IUCN Director General Dr. Bruno Oberle said in a statement. The growing list of extinct species is a "stark reminder that conservation efforts must urgently expand" and that conservation needs to become incorporated in all sectors of the economy to tackle global threats, such as unsustainable fisheries, land clearing for agriculture and invasive species.
"The conservation successes in today's Red List update provide living proof that the world can set, and meet, ambitious biodiversity targets," Dr. Jane Smart, global director of IUCN's Biodiversity Conservation Group, said in a statement. "They further highlight the need for real, measurable commitments as we formulate and implement the post-2020 global biodiversity framework."
abc news
NEW DELHI (Reuters) - India's agriculture minister said on Thursday the government was ready to consider further changes to divisive reforms that have triggered the biggest protests by farmers in years.
Narendra Singh Tomar urged farmers' leaders to come in for another round of talks to end the impasse over new agricultural legislation the government says was meant to overhaul antiquated procurement procedures and open up the market.
Huge crowds have been out on the streets around Delhi since November demanding the government repeal the laws that they say will eventually dismantle India's regulated markets and leave them at the mercy of private buyers.
Protest leaders have threatened to intensify their demonstrations from Saturday by blocking national highways and by boycotting public events held by leaders of Prime Minister Narendra Modi's ruling party.
"The government is ready to consider any additional objections of the farmers if they have any," the minister told reporters.
The ultimate aim of the legislation, he said, was to increase farmers' income. "Through these laws the government has eased restrictions on private investment in the agricultural sector," Tomar said.
The current system of procurement where the state set prices would continue, he added.
Farmers on Wednesday rejected earlier compromises from the government, including a promise that private market places could be taxed by the state governments at the same rate as state markets.
Modi's reforms, voted through in parliament in September with little debate, have particularly angered politically influential farmers groups in the crop-growing states of Punjab and Haryana.
Small farmers fear that once big corporate players enter the market, they will lose government guarantees on prices.
"There is no mention of providing legal assurance for the minimum support price for the procurement of crops," Yogendra Yadav, an opposition leader who is taking part in the protests, told Mirror Now TV channel on Thursday.
Protesters demanding the resignation of Armenian Prime Minister Nikol Pashinyan attempted to storm a government building Thursday.
The demonstrators tried the enter the building while a Cabinet meeting was being held.
Police intervened, with clashes breaking out between the two sides, and more than 40 people were arrested.
Protests erupted in Armenia last month after Pashinyan accepted defeat by signing a deal with Azerbaijan and Russia to halt fighting over the enclave of Upper Karabakh.
On Saturday, opposition parties in Armenia gave Pashinyan until Dec. 8 to resign, warning him of civil disobedience across the country if he failed to do so.
Relations between the former Soviet republics of Azerbaijan and Armenia have been tense since 1991, when the Armenian military occupied Upper Karabakh, also known as Nagorno-Karabakh, a territory recognized as part of Azerbaijan, and seven adjacent regions.
New clashes erupted on Sept. 27, and the Armenian army launched attacks on civilians and Azerbaijani forces and violated several humanitarian cease-fire agreements.
During the 44-day conflict, Azerbaijan liberated several cities and nearly 300 settlements and villages from Armenian occupation.
On Nov. 10, the two countries signed a Russian-brokered agreement to end the fighting and work toward a comprehensive resolution.
The truce is seen as a victory for Azerbaijan and a defeat for Armenia, whose armed forces have been withdrawing in line with the agreement.
The US Supreme Court ruled in favor Thursday of three Muslim men who sought to sue the FBI over either being placed on or kept on the federal government's no-fly list.
The men said they were being penalized by federal investigators for refusing to inform on their fellow co-religionists during terrorism probes.
In an unanimous opinion authored by Justice Clarence Thomas, the top court said Jameel Algibhah, Naveed Shinwari, and Muhammad Tanvir may now seek monetary compensation under US laws guaranteeing religious freedom.
Thomas wrote that the Religious Freedom Restoration Act's "express remedies provision permits litigants, when appropriate, to obtain money damages against federal officials in their individual capacities."
Newly-confirmed Justice Amy Coney Barrett did not partake in the unanimous ruling.
While the men may now seek damages, it is unclear if they will succeed in doing so. Thomas noted the fact, saying the FBI agents are entitled to invoke what is known as qualified immunity.
The legal principle sets a very high bar for law enforcement officers to be sued for actions taken on the job. It has been a flashpoint of criticism following the shootings of Black men and women by police.
All three of the men have been removed from the no-fly list./aa