Staff

Staff

The world has built up a lot of immunity in the nine months since the Omicron variant of the novel coronavirus became dominant, driving a record wave of infections.

That immunity from vaccines and past infection is helping to keep down hospitalizations and deaths even as Omicron’s offspring—a succession of subvariants—have become dominant, one after the other.

Now the virus is trying to find a way around our antibodies. A new subvariant, BA.4.6, is beginning to outcompete its predecessor, BA.5. Its advantages include a particular mutation to the spike protein, the part of the virus that helps it to grab onto and infect our cells.

We’ve seen this R346T mutation before. And every time it’s appeared, it’s been associated with forms of the SARS-CoV-2 pathogen with an increased ability to dodge our antibodies. A quality epidemiologists call “immune escape.”

If BA.4.6 becomes dominant, it could reverse the encouraging trend we’ve seen in most countries in recent weeks toward fewer infections, fewer hospitalizations, fewer deaths.

It’s a reminder that the novel coronavirus is a living, evolving thing. As we adapt to it, it adapts to us. “Viruses in general mutate to be more infectious and to avoid our immunity,” Ali Mokdad, a professor of health metrics sciences at the University of Washington Institute for Health, told The Daily Beast.

Don’t panic quite yet. “One thing I try not to do is get too excited for every new variant that pops up,” Peter Hotez, an expert in vaccine development at Baylor College, told The Daily Beast.

Most coronavirus variants and subvariants appear and disappear without significantly changing the pandemic’s overall direction. Plus, there’s a new kind of vaccine in the works that could help us to fight, long-term, even the worst forms of COVID. Eventually.

All the same, BA.4.6 warrants close attention. It’s the seventh major subvariant of Omicron, which first appeared in Africa back in November. It spread fast, outcompeting and replacing the previous major variant, Delta. Epidemiologists have described Omicron and its subvariants as the most contagious respiratory viruses they’ve ever seen.

Omicron is four times as transmissible as Delta but half as lethal. So Omicron resulted in the worst-ever day for new COVID infections when a record 4.1 million people got sick on Jan. 19. That’s a fivefold increase over Delta’s worst day back in April last year.

But just 13,000 people died on the worst day for Omicron deaths on Feb. 9—thousands fewer than died on Delta’s most lethal day back in January 2021.

It’s not hard to explain the growing gap between infections and deaths as the pandemic grinds toward its fourth year. Billions of people have been at least partially vaccinated. Billions have caught COVID and survived. The combination of vaccine-induced and natural antibodies has created a global wall of immunity that has blunted the worst outcomes.

But with BA.4.6, the virus is trying to find a way around that wall. “There’s a huge selective pressure for immune escape, especially now that the great majority of the population has some degree of immunity, from immunization, infection or both,” Keith Jerome, a University of Washington virologist, told The Daily Beast.

SARS-CoV-2 is, in essence, fighting for its own survival—trying out mutations until it settles on one that might give it the upper hand.

R346T is one of those mutations. It’s not totally clear how the virus came up with the change. It’s possible Omicron mixed with an older form of SARS-CoV-2 in a person who’s gotten sick more than once. It’s possible, in other words, that BA.4.6 is a “recombinant” subvariant that picked up its most advantageous quality from one of its predecessors.

That one change to the spike protein appears to make the virus somewhat harder for our antibodies to recognize. With R346T, the virus has a better chance of slipping right past our immune systems and causing an infection. Even if we’ve been vaccinated. Even if we’ve also caught and gotten over COVID in the past.

Greater immune escape means more and worse infections. We’ve been lucky with Omicron in the sense that, even as the variant and its subvariants have driven back-to-back-to-back waves in cases since November, hospitalizations and deaths haven’t risen in proportion.

It’s still an open question how much worse BA.4.6 might be and how far it might spread. Health agencies all over the world have been tracking the subvariant for months now. As BA.5 cases plateau, BA.4.6 is outcompeting BA.5—but not everywhere.

The BA.4.6 hotspots include some Australian states and parts of the U.S. Midwest. So far, BA.4.6 accounts for around four percent of new cases in the U.S., Canada and the United Kingdom.

The proportion of BA.4.6 is set to rise as BA.5 declines. BA.4.6 appears to have only a 10-percent growth advantage over BA.5, but that advantage has been growing over time.

If there’s good news in BA.4.6’s rise, it’s that for all its worrying mutations it’s still an Omicron sublineage—and still has a lot of mutations in common with BA.5, BA.4, BA.2 and BA.1.

That means the Omicron-specific boosters that Pfizer and Moderna are developing for their messenger-RNA vaccines, and which U.S. regulators are on track to approve in coming weeks, should still work at least somewhat against BA.4.6.

BA.4.6 isn’t the worst case scenario. That would be a subvariant—or brand-new variant—with strong immune escape, a form of SARS-CoV-2 that has mutated so much that all those antibodies we’ve built up over the past three years barely recognize it.

The epidemiological community is divided over how likely this variant is to evolve. Some are confident that respiratory viruses such as the flu and the novel coronavirus tend to get overall milder over time as they become “endemic”—that is, always present but usually manageable.

Others fear near-total immune escape is all but inevitable for cleverer viruses as they tirelessly fight to survive. “This idea that each subsequent variant causes less severe illness—I don’t buy that,” Hotez said.

It comes down to genetics—the virus trading one quality for another as it strives to spread to more and more hosts. “The trick for the virus is to find a way to escape immunity while still maintaining the ability to infect new people efficiently,” Jerome explained.

“The virus has been very successful so far at doing so, but the big question is whether it can continue to do so, or instead will ultimately exhaust all the possible tricks to do so, and settle down into a more manageable level of endemicity. There’s no way to know for sure yet.”

A variant or subvariant with near-total immune escape could drag us back to the most terrifying days of the early pandemic, when almost no one had immunity—or any way of developing immunity without surviving a very dangerous infection.

But BA.4.6 with its R346T mutation and potential for immune escape might be a preview of that worst-case scenario. It might also be an argument for the pharmaceutical industry and health agencies to redouble their efforts to create universal vaccines that work against SARS-CoV-2 and every other major coronavirus, of which there are scores.

There are around a dozen major “pan-coronavirus” vaccines in development. The two leading efforts are at the Coalition for Epidemic Preparedness Innovations in Norway and the U.S. government’s National Institute of Allergy and Infectious Diseases.

They’re spending $200 million and $43 million, respectively, to develop their new universal jabs. Trials are still months, if not years, away. “We’re moving piecemeal toward a more universal coronavirus vaccine,” Hotez said.

Pan-coronavirus vaccines might be slightly less effective than the best mRNA vaccines were at their peak effectiveness (against serious illness and death) of more than 90 percent, back in late 2020.

But they’d be broadly effective, keeping people alive and out of the hospital even as the virus mutates again and again in order to survive./ The Daily Beast

Roughly 21,000 fish died at a northern California university’s aquatic research center overnight last week, according to a university statement.  

“The loss appears to be due to chlorine exposure, to which fish are especially sensitive,” the statement from University California Davis read. Among the dead fish were green and white sturgeon as well as the endangered Chinook salmon.

They were being used to research “bioenergetics and environmental stressors” on different species, according to the statement, which said it would launch an investigation into how the center’s “process failed."

“We share the grief of the faculty, staff and students who worked to care for, study and conserve these animals,” the statement read. “We commit to understanding what happened and making changes to the facility so that we can ensure that this does not happen again.”

Chlorine is used as a decontaminant and is often found in tap water. That is why using tap water in fish tanks is not recommended without the use of a dechlorinator, according to the Florida Department of Agriculture. 

An undated photo of green sturgeon at the Center for Aquatic Biology and Aquaculture at UC Davis.

The university believes that there was a failure in an external decontamination system that caused the chlorinated water to back up in the fish tanks, Andy Fell, a university spokesperson, told USA TODAY.

“These were currently, basically, all the fish they maintained in those outdoor tanks so this was a total loss for the center,” Fell said. “It was really a devastating thing to happen.”

None of the various other aquatic research facilities at UC Davis were affected by the situation, the university said in its statement. But it planned to assess the risk at some facilities that have potential for similar chlorine exposure.

The fish died at UC Davis’ Center for Aquatic Biology and Aquaculture where research aimed at protecting the state’s aquatic resources is conducted, according to the center’s website.

About 100 fish survived, according to Fell, and the university is providing mental health resources to the center’s staff./US Today

A court in military-ruled Myanmar has sentenced deposed leader Aung San Suu Kyi to six years in prison after finding her guilty in four corruption cases. 

Suu Kyi was sentenced to "six years imprisonment under four anti-corruption charges", said a source with knowledge of the proceedings on Monday, requesting anonymity.

The figurehead of Myanmar's opposition to military rule has been charged with at least 18 offences ranging from graft to election violations, carrying combined maximum jail terms of nearly 190 years.

Suu Kyi had called the accusations absurd and denies all charges against her.

She was found guilty on Monday of misusing funds from the Daw Khin Kyi Foundation - an organisation she founded promoting health and education - to build a home, and leasing government-owned land at a discounted rate, the source said. 

Suu Kyi, who is being held in solitary confinement in a jail in the capital Naypyitaw, had already been sentenced to 11 years prison in other cases.

Myanmar has been in turmoil since last year when the military overthrew an elected government led by Suu Kyi's party, after it won a general election, and led a deadly crackdown on dissent. 

Tens of thousands of people have been jailed and many tortured, beaten or killed, in what the United Nations has called crimes against humanity.

'Massive assault against her rights'

The international community has imposed sanctions on the military and dismissed Suu Kyi's secretive trials as farcical.

"It's a massive assault against her rights, and part of the campaign to bury her and the NLD forever," said Phil Robertson, deputy Asia director at Human Rights Watch, referring to her ousted party, the National League for Democracy. 

The military government's spokesperson Zaw Min Tun could not be reached for comment on Monday. 

It has previously said Suu Kyi is being given due process by an independent judiciary and rejects foreign criticism as interference. 

The daughter of the leader of Myanmar's campaign for independence from British colonial led the country for five years during a brief period of tentative reforms before being forced from power in the February 2021 coup.

The military has ruled for five of the past six decades.

Source: Reuters

Lawyers for WikiLeaks founder Julian Assange have sued the US Central Intelligence Agency (CIA) and its former director Mike Pompeo, alleging it recorded their conversations and copied data from their phones and computers.

The attorneys, along with two journalists also joining Monday's suit, are Americans and allege that the CIA violated their US constitutional protections for confidential discussions with Assange, who is Australian.

They said the CIA worked with a security firm contracted by the Ecuadoran embassy in London, where Assange was living at the time, to spy on the Wikileaks founder, his lawyers, journalists and others he met with.

Assange is facing extradition from Britain to the US, where he is charged with publishing US military and diplomatic files in 2010 related to the Afghanistan and Iraq wars.

Robert Boyle, a New York attorney representing the plaintiffs in the lawsuit, said the alleged spying on Assange's attorneys means the Wikileaks founder's right to a fair trial has "now been tainted, if not destroyed."

"The recording of meetings with friends, with lawyers and the copying of his attorneys' and friends' digital information taints the criminal prosecution because now the government knows the contents of those communications," Boyle told reporters.

"There should be sanctions, even up to dismissal of those charges, or withdrawal of an extradition request in response to these blatantly unconstitutional activities," he said.

Violation of privacy protections

The suit was filed by attorneys Margaret Ratner Kunstler and Deborah Hrbek, and journalists Charles Glass and John Goetz.

They all visited Assange while he was living inside the Ecuadoran embassy in London under political asylum, since withdrawn.

The suit named the CIA, former CIA director and former US secretary of state Pompeo, and the security firm Undercover Global and its chief executive David Morales Guillen.

It said Undercover Global, which had a security contract with the embassy, swept information on their electronic devices, including communications with Assange, and provided it to the CIA.

In addition it placed microphones around the embassy and sent recordings, as well as footage from security cameras, to the CIA. This, the attorneys said, violated privacy protections for US citizens.

Assange is awaiting a ruling on his appeal of the British extradition order to the United States. The charges he faces under the US Espionage Act could bring a sentence of up to 175 years in prison.

Source: AFP

An area of intensely warm weather, the so-called "extreme heat belt", with at least one day per year in which the heat index hits 52C, is now expected to spread and cover a region home to more than 100 million people by the year 2053, according to a new study.

The research, carried out by the nonprofit First Street Foundation, used a peer-reviewed model built with public and third-party data to estimate heat risk at what they called a "hyper-local" scale of 30 square metres.

First Street Foundation's mission is to make climate risk modelling accessible to public, government and industry representatives, such as real estate investors and insurers.

A key finding from the study was that heat exceeding the threshold of the National Weather Service's highest category, called "Extreme Danger," or above 51.7C, was expected to impact 8.1 million people in 2023 and grow to 107 million people in 2053, a 13-fold increase.

This would encompass a geographic region stretching from northern Texas and Louisiana to Illinois, Indiana, and Wisconsin – inland areas far from the more temperate weather often seen near the coasts.

Heat index, also known as the apparent temperature, is what the outside temperature really feels like to the human body when relative humidity is combined with air temperature.

How the model works

To create their model, the research team examined satellite-derived land surface temperatures and air temperatures between 2014 and 2020, to help understand the exact relationship between the two measurements.

This information was further studied by factoring in elevation, how water is absorbed in the area, the distance to surface water and the distance to a coast.

The model was then scaled to future climate conditions, using a "middle of the road" scenario envisaged by the Intergovernmental Panel on Climate Change, in which carbon dioxide levels start falling by mid-century, but do not reach net zero by 2100.

Significant local temperature increases on horizon

Beyond "Extreme Danger" days, areas across the whole country are expected to experience hotter temperatures, with varying degrees of resilience.

"These increases in local temperatures result in significant implications for communities that are not acclimated to warmer weather relative to their normal climate," the report said.

For example, a 10 percent temperature increase in the northeastern state of Maine may be as dangerous as a 10 percent increase in the southwestern state of Texas, despite the higher absolute temperatures seen in Texas.

The biggest predicted shift in local temperature occurred in Miami-Dade County, Florida, which currently sees seven days per year at its hottest temperature of 39.4C. By 2053, that number is expected to increase to 34 days.

And the increase in air conditioning use that is likely to result from such temperature spikes will strain energy grids, the report warned, leading to more frequent, longer-lasting brownouts, a temporary reduction in voltage.

Source: AFP

Salah Al-Masad, Head of Fatwa and Legislation, stated that in 1976, the Arbitration Court was established under the supervision of the International Center for Settlement of Investment Disputes affiliated with the World Bank in Washington, under the rules of the United Nations Commission on International Trade Law (UNCITRAL), issued a ruling yesterday in the interest of Kuwait in response to the pleas submitted by the Kuwait Government on behalf of Kuwait in an arbitration dispute brought by the plaintiff, Maria Lazareva, against Kuwait, under Kuwait's Bilateral Investment Promotion and Protection Agreement with the Russian Federation.

According to Al-Masad, the plaintiff, Lazareva, filed a lawsuit against Kuwait under the Bilateral Investment Promotion and Protection Agreement on July 15, 2018. She claims the value of the investment she made in Kuwait and the lost profits, as well as compensation for Kuwait's abuse of criminal and legal procedures, according to her claims.

Moreover, he explained that the plaintiff claimed that Kuwait's criminal justice system did not meet international standards and that Kuwait was in violation of the contract's terms. In light of the plaintiff's allegations of direct investment in Kuwait, he requested compensation for moral damage and material losses.

A majority of the court decided by a majority not to consider the case for lack of jurisdiction as the arbitration tribunal won Kuwait's right and defense presented by its legal team, and Kuwait's right was won by the arbitration tribunal. He explained that the plaintiff was unable to meet the required investment criteria contained in the agreement regarding participation and control, which disqualified her from receiving the guarantees provided to foreign investors.

As a result of the court's decision, Kuwait will receive legal fees worth approximately $3.768 million, which the plaintiff Lazareva must pay Kuwait within 60 days. This success is added to the others that Kuwait has won before various arbitration centers, such as the Permanent Court of Arbitration in The Hague and the International Center for Settlement of Investment Disputes.

As a result of the Fatwa and Legislation team's efforts over the past four years, the ruling was issued, and Al-Massad praised their accomplishments./KT

 Kuwait has sent its first ambassador to Tehran since a downgrading of relations in 2016, Iran has announced. Kuwait recalled its ambassador and the United Arab Emirates downgraded relations with Iran after Saudi Arabia that year cut ties with its regional rival, with Bahrain following suit. That came after Iranian protesters attacked Saudi diplomatic missions in Iran following Riyadh’s execution of Shiite cleric Nimr Al-Nimr.

Bader Abdullah Al-Munaikh, Kuwait’s new ambassador, presented his credentials to Iranian Foreign Minister Hossein Amir-Abdollahian, the official IRNA news agency reported on Saturday night. Kuwait’s foreign ministry confirmed Munaikh was appointed envoy to Iran. Iran already has an ambassador in Kuwait. Kuwait has maintained relatively good relations with Tehran under a foreign policy balancing ties with its larger neighbors.

Saudi Arabia and Iran have had no diplomatic relations for six years, but have held talks, hosted by Iraq, since April last year in a bid to mend ties. The kingdom’s foreign minister has said there has been some progress in five rounds of discussions, but “not enough”. The UAE said in July it was “considering” appointing an ambassador to Tehran, which Iran said it expected “soon”. – Agencies

Gunfire and a subsequent explosion have left at least five people dead, 15 wounded with several others missing in the Ecuadoran port city of Guayaquil. 

Government officials blamed the attack on organised crime. 

Interior Minister Patricio Carrillo said "organised-crime mercenaries," long involved in illicit drug traffic, were "now attacking with explosives."

"It is a declaration of war against the state," Carrillo added on Twitter.

Eight houses and two cars were destroyed in the blast in Guayaquil, the country's second-largest city, according to the Secretariat for Risk Management.

On its Twitter account, Ecuador's Prosecutor's Office said its agents were gathering evidence to establish the cause and motive for the attack in Guayaquil's Cristo del Consuelo neighbourhood.

Guayaquil, 270 kilometres southwest of the capital Quito, has seen frequent shootings and killings by members of rival gangs believed to have links to national and international drug trafficking. 

Dozens were killed last year in massacres inside the largest state prison in the city./agencies

Is everyone on vacation?

That would be one plausible explanation behind the great box office slowdown. Although three new movies opened nationwide, none were able to crack the top five on domestic charts and only two –– A24's satirical slasher "Bodies Bodies Bodies" and Lionsgate's vertigo-inducing thriller "Fall" –– managed to break into the top 10.

It's even more dire that Sony's action-thriller "Bullet Train," which claimed the top spot for the second weekend in a row with $13.1 million from 4,357 North American locations, was the sole film to bank at least $10 million in ticket sales.

After two weeks on the big screen, the Brad Pitt-led "Bullet Train" has generated $54.4 million at the domestic box office.  

Pitt, who plays a professional assassin on a Japanese train seemingly loaded with them, heads a cast that includes Joey King, Aaron Taylor-Johnson and Latin music star Bad Bunny, as well as Sandra Bullock and Channing Tatum in bit roles.

This weekend marks the first time since February 11-13 –– when "Death on the Nile" opened to a weak $12.3 million and Jennifer Lopez's romantic comedy "Marry Me" stumbled with even less ––that only one movie reached at least $10 million between Friday and Sunday.

And the glacial drip, drip, drip of ticket sales is only going to worsen as the box office heads for a near desolate stretch with hardly any new offerings from major studios on the horizon. 

While cinema owners brace for the downtrend, they are bowing at the altar of Harry Styles in hopes the pop heartthrob will inspire audiences to return to cinemas in droves for director Olivia Wilde's mind-bender "Don't Worry Darling," which doesn't open until September 23. 

Until then, exhibitors will have to make do with smaller thrillers and dramas like Idris Elba's "Beast," which is coming on August 19; "Three Thousand Years of Longing," a fantasy romance with Tilda Swinton and Elba (again) on August 26; and the Viola Davis-led historical epic "The Woman King" on September 16.

New entrants

In eighth place, "Bodies Bodies Bodies" beat expectations with $3.2 million from 1,290 locations. 

After kicking off last weekend in limited release, the movie has grossed $3.5 million to date and plans to expand to 2,000+ cinemas next weekend. But otherwise, audiences wanted little to do with "Fall" and Diane Keaton's body-swap comedy "Mack & Rita," the other movie that debuted over the weekend.

"Fall" just barely landed in 10th place with $2.5 million from 1,548 venues. 

The movie, centring on two best friends who climb 2,000 feet to the top of an abandoned radio tower and find themselves stranded with no way down, was relatively low risk for Lionsgate as it cost only $3 million to produce and less than $4 million to promote. It won't take much coinage to turn a profit, and home entertainment will be helpful with that mission.

Elsewhere, Steven Spielberg's science-fiction classic "E.T." –– which debuted 40 years ago –– grossed more money over the weekend than Keaton's "Mack and Rita." The Gravitas Ventures release premiered in 13th place with $1.03 million from 1,930 screens. Universal's re-release of "E.T." raked in $1.07 million from only 389 Imax screens.

As expected, "Mack and Rita" brought out mostly older women, with 74 percent of ticket buyers identifying as female and 69 percent over the age of 30. They were not kind to the movie, which landed a "D+" CinemaScore. Reviews were equally harsh, resulting in a bleak 26 percent score on Rotten Tomatoes.

‘Top Gun’ edges closer breaking ‘Avengers’ record

With the dismal turnout for most other movies, Paramount's ever-powerful blockbuster "Top Gun: Maverick" swooped to second place in its 12th weekend of release. 

The action sequel added $7.1 million from 3,181 venues over the weekend, bringing its domestic tally to $673.8 million. That means "Maverick" is roughly $5 million away from dethroning Marvel's "Avengers: Infinity War" as the sixth-highest-grossing movie in domestic box office history.

Source: Reuters

Europe's blistering summer may not be over yet but 2022 is already breaking records, with nearly 660,000 hectares ravaged since January, according to the EU's satellite monitoring service.

And while countries on the Mediterranean have normally been the main seats of fires in Europe, other countries are also suffering heavily this year.

Fires this year have forced people to flee their homes, destroyed buildings and burned forests in EU countries, including Austria, Croatia, France, Greece, Italy, Portugal and Spain.

Some 659,541 hectares (1.6 million acres) have been destroyed, data from the European Forest Fire Information System (EFFIS) showed, setting a record at this point in the year since data collection began in 2006.

Europe has suffered a series of heat waves, forest fires and historic drought that experts say are being driven by human-induced climate change.

They warn more frequent and longer heatwaves are on the way.

For nearly two weeks last month, thousands of firefighters struggled to put out Slovenia's largest wildfire in its modern history.

But the worst-affected country has been Spain, where fire has destroyed 244,924 hectares, according to EFFIS data, followed by Romania (150,528 hectares) and Portugal (77,292 hectares).

The EFFIS uses satellite data from the EU's Copernicus Atmosphere Monitoring Service (CAMS).

The data comes after CAMS said on Friday that 2022 was a record year for wildfire activity in southwestern Europe and warned that a large proportion of western Europe was now in "extreme fire danger".

"On 2022, it is already a record year, just below 2017," EFFIS coordinator Jesus San-Miguel said. 

In 2017, 420,913 hectares burned by August 13, rising to 988,087 hectares by the end of the year.

"The situation in terms of drought and extremely high temperatures has affected all Europe this year and the overall situation in the region is worrying, while we are still in the middle of the fire season," he said.

Since 2010, there had been a trend towards more fires in central and northern Europe, with fires in countries that "normally do not experience fires in their territory", he added.

"The overall fire season in the EU is really driven mainly by countries in the Mediterranean region, except in years like this one, in which fires also happen in central and northern regions," he added.

Source: AFP

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